3BFT

Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CAC B1439

Chain	Residue
B	ARG163
B	GLU166
B	SER168
B	PHE170
B	ZN1005
B	HOH1553
C	GLU42
C	LYS45
C	HIS46

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B1001

Chain	Residue
A	HIS23
B	HIS23
B	GLU30

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A1002

Chain	Residue
A	GLU42
A	LYS45
A	HIS46

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A1003

Chain	Residue
A	ASP65
C	HIS23

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1004

Chain	Residue
B	GLU42
B	HIS46
B	LEU241
C	GLU166

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B1005

Chain	Residue
B	GLU166
B	CAC1439
C	GLU42
C	HIS46

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B1006

Chain	Residue
B	ASP156
B	HOH1541
B	HOH1605

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A1007

Chain	Residue
A	ASP156
A	HOH1119
A	HOH1137

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A1008

Chain	Residue
A	THR5
A	HOH1144

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE S2P A1009

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	GLU193
A	MET196
A	HOH1148

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE S2P B1440

Chain	Residue
B	TYR61
B	PRO89
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	LEU192
B	GLU193
B	MET196
B	HOH1649

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE S2P C 264

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	GLY141
C	SER142
C	THR143
C	GLU193
C	MET196
C	HOH293
C	HOH436
C	HOH446

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---