3B6W

Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution

Summary for 3B6W

Entry DOI	10.2210/pdb3b6w/pdb
Related	1FTJ 1FTO 1P1U 3B6Q 3B6T
Descriptor	Glutamate receptor 2, SULFATE ION, GLUTAMIC ACID, ... (4 entities in total)
Functional Keywords	glur2, t686s, mutant, ampa receptor, ionotropic glutamate receptor, alternative splicing, cell junction, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphorylation, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	4
Total formula weight	117509.14
Authors	Cho, Y.,Lolis, E.,Howe, J.R. (deposition date: 2007-10-29, release date: 2008-02-05, Last modification date: 2021-10-20)
Primary citation	Zhang, W.,Cho, Y.,Lolis, E.,Howe, J.R. Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J.Neurosci., 28:932-943, 2008 Cited by PubMed: 18216201 DOI: 10.1523/JNEUROSCI.3309-07.2008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation