3B6W

Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	ARG660
A	TRP671

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 801

Chain	Residue
A	THR655
A	GLU705
A	TYR732
A	HOH1034
A	HOH1091
A	HOH1092
A	TYR450
A	PRO478
A	LEU479
A	THR480
A	ARG485
A	GLY653
A	SER654

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	ALA452
A	ASP651
A	SER652
A	LYS656
A	ARG660
A	HOH1082

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 801

Chain	Residue
B	TYR450
B	PRO478
B	LEU479
B	THR480
B	ARG485
B	GLY653
B	SER654
B	THR655
B	GLU705
B	TYR732
B	HOH916
B	HOH987
B	HOH996

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 904

Chain	Residue
B	ALA452
B	ASP651
B	SER652
B	LYS656
B	ARG660
B	HOH932
B	HOH1014

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 902

Chain	Residue
C	THR480
C	ARG485
C	GLY653
C	SER654
C	HOH922

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO478
B	SER654
B	THR655
B	GLU705
C	PRO478
C	THR480
C	ARG485
C	SER654
C	THR655
C	GLU705
D	PRO478
A	THR480
D	THR480
D	ARG485
D	SER654
D	THR655
D	GLU705
A	ARG485
A	SER654
A	THR655
A	GLU705
B	PRO478
B	THR480
B	ARG485

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG453
D	ARG453
D	ARG660
D	LYS752
A	ARG660
A	LYS752
B	ARG453
B	ARG660
B	LYS752
C	ARG453
C	ARG660
C	LYS752

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE633
B	ILE633
C	ILE633
D	ILE633

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER662
B	SER662
C	SER662
D	SER662

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER696
B	SER696
C	SER696
D	SER696

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN392
B	ASN392
C	ASN392
D	ASN392

---