3B6W

Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2	polymer	263	29207.7	4	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Norway rat)	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
2	A, B, C	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	A, B	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU)
4		water	water		18.0	581	Chemie (HOH)

Sequence modifications

A, B, C, D: 392 - 506 (UniProt: P19491)

PDB	External Database	Details
Gly 390	-	expression tag
Ala 391	-	expression tag

A, B, C, D: 632 - 775 (UniProt: P19491)

PDB	External Database	Details
Gly 630	-	linker
Thr 631	-	linker
Ser 686	Thr 707	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	116830.6
Non-Polymers*	Number of molecules	6
	Total formula weight	678.5
All*	Total formula weight	117509.1

*Water molecules are not included.