3BBR

Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution

Summary for 3BBR

• Entry DOI: 10.2210/pdb3bbr/pdb
• Related: 1LBC 2AL4 2AL5
• Descriptor: Glutamate receptor 2, SULFATE ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: ampa receptor, glur2, s1s2, ligand binding core, point mutation, n775s, dimeric positive modulator, agonist, cell junction, glycoprotein, ion transport, ionic channel, lipoprotein, membrane, palmitate, phosphorylation, postsynaptic cell membrane, rna editing, synapse, transmembrane, transport, membrane protein
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P19491
• Total number of polymer chains: 2
• Total formula weight: 59808.11

Authors

Kastrup, J.S.,Gajhede, M. (deposition date: 2007-11-11, release date: 2007-12-04, Last modification date: 2023-11-01)

• Primary citation: Kaae, B.H.,Harpsoe, K.,Kastrup, J.S.,Sanz, A.C.,Pickering, D.S.,Metzler, B.,Clausen, R.P.,Gajhede, M.,Sauerberg, P.,Liljefors, T.,Madsen, U.; Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites; Chem.Biol., 14:1294-1303, 2007; PubMed: 18022568; DOI: 10.1016/j.chembiol.2007.10.012

Experimental method

X-RAY DIFFRACTION (2.25 Å)