Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 264 |
| Chain | Residue |
| B | ARG148 |
| B | TRP159 |
| B | ARG163 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 265 |
| Chain | Residue |
| B | HOH399 |
| B | HOH442 |
| B | ASP139 |
| B | SER140 |
| B | LYS144 |
| B | ARG148 |
| B | HOH297 |
| B | HOH379 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 264 |
| Chain | Residue |
| A | SER140 |
| A | LYS144 |
| A | ARG148 |
| A | HOH295 |
| A | HOH312 |
| A | HOH366 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 266 |
| Chain | Residue |
| B | HIS23 |
| B | ARG31 |
| B | HOH285 |
| B | HOH523 |
| B | HOH534 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 265 |
| Chain | Residue |
| A | ARG31 |
| A | HOH294 |
| A | HOH318 |
| A | HOH328 |
| A | HOH461 |
| B | LYS183 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 266 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GLU A 267 |
| Chain | Residue |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | TYR220 |
| A | HOH281 |
| A | HOH282 |
| A | HOH304 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 267 |
| Chain | Residue |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| B | TYR220 |
| B | HOH276 |
| B | HOH287 |
| B | HOH298 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE BHY A 268 |
| Chain | Residue |
| A | LYS104 |
| A | PRO105 |
| A | MET107 |
| A | SER108 |
| A | SER217 |
| A | LYS218 |
| A | GLY219 |
| A | LEU239 |
| A | HOH416 |
| A | HOH437 |
| B | LYS104 |
| B | PRO105 |
| B | MET107 |
| B | SER108 |
| B | SER217 |
| B | LYS218 |
| B | GLY219 |
| B | LEU239 |
| B | SER242 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 268 |
| Chain | Residue |
| B | TYR161 |
| B | SER164 |
| B | ALA165 |
| B | GLU166 |
| B | HOH425 |
| B | HOH457 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 269 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | ALA134-VAL154 | |
| A | ASP207-GLY227 | |
| B | ALA134-VAL154 | |
| B | ASP207-GLY227 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 62 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | PHE155-VAL181 | |
| A | GLU201-CYS206 | |
| B | PHE155-VAL181 | |
| B | GLU201-CYS206 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | ARG182-ASN197 | |
| B | ARG182-ASN197 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | INTRAMEM: |
| Chain | Residue | Details |
| A | GLU198-ILE200 | |
| B | GLU198-ILE200 | |
| Chain | Residue | Details |
| A | PRO89 | |
| B | SER142 | |
| B | THR143 | |
| B | GLU193 | |
| A | THR91 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| B | PRO89 | |
| B | THR91 | |
| B | ARG96 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| B | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| B | SER184 | |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE200 | |
| B | ILE200 | |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| B | ASN3 | |
