4NWC
Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.
Summary for 4NWC
Entry DOI | 10.2210/pdb4nwc/pdb |
Related | 3S9E 4MH5 |
Descriptor | Glutamate receptor ionotropic, kainate 3, POTASSIUM ION, PHOSPHATE ION, ... (6 entities in total) |
Functional Keywords | kainate receptor ligand-binding domain, agonist, ionotropic glutamate receptor, membrane protein, receptor-agonist complex, receptor/agonist |
Biological source | Rattus norvegicus (brown rat,rat,rats) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P42264 |
Total number of polymer chains | 1 |
Total formula weight | 29534.29 |
Authors | Larsen, A.P.,Venskutonyte, R.,Frydenvang, K.,Gajhede, M.,Kastrup, J.S. (deposition date: 2013-12-06, release date: 2014-08-06, Last modification date: 2023-09-20) |
Primary citation | Venskutonyte, R.,Larsen, A.P.,Frydenvang, K.,Gajhede, M.,Sagot, E.,Assaf, Z.,Gefflaut, T.,Pickering, D.S.,Bunch, L.,Kastrup, J.S. Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9:2254-2259, 2014 Cited by PubMed: 25044437DOI: 10.1002/cmdc.201402204 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.012 Å) |
Structure validation
Download full validation report