4MN5
| Crystal structure of PAS domain of S. aureus YycG | 分子名称: | Sensor protein kinase WalK, ZINC ION | 著者 | Shaikh, N, Hvorup, R, Winnen, B, Collins, B.M, King, G.F. | 登録日 | 2013-09-10 | 公開日 | 2014-09-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of PAS domain of S. aureus YycG To be Published
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3FL2
| Crystal structure of the ring domain of the E3 ubiquitin-protein ligase UHRF1 | 分子名称: | E3 ubiquitin-protein ligase UHRF1, ZINC ION | 著者 | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-12-18 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure of the Ring Domain of the E3 Ubiquitin-Protein Ligase Uhrf1 To be Published
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7L7S
| Human mitochondrial chaperonin mHsp60 | 分子名称: | 60 kDa heat shock protein, mitochondrial | 著者 | Chen, L, Wang, J.C.Y. | 登録日 | 2020-12-30 | 公開日 | 2021-08-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60. Sci Rep, 11, 2021
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6U5H
| CryoEM Structure of Pyocin R2 - precontracted - hub | 分子名称: | Probable bacteriophage protein Pyocin R2 | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
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4MML
| D40A Hfq from Pseudomonas aeruginosa | 分子名称: | MAGNESIUM ION, Protein hfq, SULFATE ION, ... | 著者 | Murina, V.N, Filimonov, V.V, Melnik, B.S, Uhlein, M, Mueller, U, Weiss, M, Nikulin, A.D. | 登録日 | 2013-09-09 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Effect of conserved intersubunit amino Acid substitutions on hfq protein structure and stability. Biochemistry Mosc., 79, 2014
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1C1B
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186 | 分子名称: | 6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL, HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN) | 著者 | Hopkins, A.L, Ren, J, Tanaka, H, Baba, B, Okamato, M, Stuart, D.I, Stammers, D.K. | 登録日 | 1999-07-21 | 公開日 | 2000-07-21 | 最終更新日 | 2014-11-12 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants. J.Med.Chem., 42, 1999
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5F8P
| A Novel Inhibitor of the Obesity-Related Protein FTO | 分子名称: | 2-OXOGLUTARIC ACID, 4-chloranyl-6-[(2~{S})-6-chloranyl-2,4,4-trimethyl-7-oxidanyl-3~{H}-chromen-2-yl]benzene-1,3-diol, Alpha-ketoglutarate-dependent dioxygenase FTO, ... | 著者 | Chai, J, Zhou, B, Liu, W, Han, Z. | 登録日 | 2015-12-09 | 公開日 | 2016-12-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of FTO-CHTB To Be Published
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7LFC
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7LF4
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7LET
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7LEQ
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5FCW
| HDAC8 Complexed with a Hydroxamic Acid | 分子名称: | 4-naphthalen-1-yl-~{N}-oxidanyl-benzamide, GLYCEROL, HEXAETHYLENE GLYCOL, ... | 著者 | Cole, K.E, Perry, K. | 登録日 | 2015-12-15 | 公開日 | 2016-10-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | 主引用文献 | Structure of 'linkerless' hydroxamic acid inhibitor-HDAC8 complex confirms the formation of an isoform-specific subpocket. J.Struct.Biol., 195, 2016
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5FPM
| Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site. | 分子名称: | 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL, HEAT SHOCK-RELATED 70KDA PROTEIN 2 | 著者 | Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. | 登録日 | 2015-12-02 | 公開日 | 2015-12-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
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6U5K
| CryoEM Structure of Pyocin R2 - postcontracted - baseplate | 分子名称: | Glue PA0627, Sheath Initiator PA0617, Sheath PA0622, ... | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | 登録日 | 2019-08-27 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Action of a minimal contractile bactericidal nanomachine. Nature, 580, 2020
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4O4R
| Murine Norovirus RdRp in complex with PPNDS | 分子名称: | 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, RNA-dependent-RNA-polymerase, SULFATE ION | 著者 | Croci, R, Tarantino, D, Milani, M, Pezzullo, M, Bolognesi, M, Mastrangelo, E. | 登録日 | 2013-12-19 | 公開日 | 2014-11-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. Febs Lett., 588, 2014
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5FPT
| Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 2-(1-methyl-1H-indol-3-yl)acetic acid (AT3437) in an alternate binding site. | 分子名称: | (1-methyl-1H-indol-3-yl)acetic acid, HEPATITIS C VIRUS FULL-LENGTH NS3 COMPLEX | 著者 | Jhoti, H, Ludlow, R.F, Saini, H.K, Tickle, I.J, Verdonk, M, Pathuri, P, Williams, P.A. | 登録日 | 2015-12-02 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
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5GG6
| Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-dGTP | 分子名称: | 1,2-ETHANEDIOL, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | 著者 | Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. | 登録日 | 2016-06-15 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
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5GGB
| Crystal structure of Mycobacterium smegmatis MutT1 in complex with 8-oxo-dGDP | 分子名称: | 2'-deoxy-8-oxoguanosine 5'-(trihydrogen diphosphate), Hydrolase, NUDIX family protein | 著者 | Arif, S.M, Patil, A.G, Varshney, U, Vijayan, M. | 登録日 | 2016-06-15 | 公開日 | 2017-04-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Biochemical and structural studies of Mycobacterium smegmatis MutT1, a sanitization enzyme with unusual modes of association Acta Crystallogr D Struct Biol, 73, 2017
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5GQE
| Crystal structure of michaelis complex of xylanase mutant (T82A, N127S, and E128H) from Streptomyces olivaceoviridis E-86 | 分子名称: | Beta-xylanase, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, ... | 著者 | Suzuki, R, Fujimoto, Z, Kaneko, S, Kuno, A. | 登録日 | 2016-08-07 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Azidolysis by the Formation of Stable Ser-His Catalytic Dyad in a Glycoside Hydrolase Family 10 Xylanase Mutant J.Appl.Glyosci., 65, 2019
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5GL2
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4OUF
| Crystal Structure of CBP bromodomain | 分子名称: | 1,2-ETHANEDIOL, CREB-binding protein, DI(HYDROXYETHYL)ETHER | 著者 | Roy, S, Das, C, Tyler, J.K, Kutateladze, T.G. | 登録日 | 2014-02-17 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proc.Natl.Acad.Sci.USA, 111, 2014
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5G3M
| Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor. | 分子名称: | 4-BENZYLBENZAMIDE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Sandmark, J, Bodin, C, Hallberg, K. | 登録日 | 2016-04-29 | 公開日 | 2016-09-14 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease Acs Med.Chem.Lett., 7, 2016
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8DGO
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1MJB
| Crystal structure of yeast Esa1 histone acetyltransferase E338Q mutant complexed with acetyl coenzyme A | 分子名称: | ACETYL COENZYME *A, Esa1 protein | 著者 | Yan, Y, Harper, S, Speicher, D, Marmorstein, R. | 登録日 | 2002-08-27 | 公開日 | 2002-10-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate. Nat.Struct.Biol., 9, 2002
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1MJS
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