4OUF

Crystal Structure of CBP bromodomain

Summary for 4OUF

DescriptorCREB-binding protein, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstransferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q92793
Total number of polymer chains2
Total molecular weight28050.16
Authors
Roy, S.,Das, C.,Tyler, J.K.,Kutateladze, T.G. (deposition date: 2014-02-17, release date: 2014-03-12, Last modification date: 2014-04-30)
Primary citation
Das, C.,Roy, S.,Namjoshi, S.,Malarkey, C.S.,Jones, D.N.,Kutateladze, T.G.,Churchill, M.E.,Tyler, J.K.
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
Proc.Natl.Acad.Sci.USA, 111:E1072-E1081, 2014
PubMed: 24616510 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1319122111
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.191900.9%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload