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5G3M

Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor.

Summary for 5G3M
Entry DOI10.2210/pdb5g3m/pdb
Related5G3N
DescriptorGROUP 10 SECRETORY PHOSPHOLIPASE A2, CALCIUM ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordshydrolase, spla2, cardiovascular disease, inhibitor, fragment
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted : O15496
Total number of polymer chains2
Total formula weight29740.39
Authors
Sandmark, J.,Bodin, C.,Hallberg, K. (deposition date: 2016-04-29, release date: 2016-09-14, Last modification date: 2018-04-04)
Primary citationGiordanetto, F.,Pettersen, D.,Starke, I.,Nordberg, P.,Dahlstrom, M.,Knerr, L.,Selmi, N.,Rosengren, B.,Larsson, L.O.,Sandmark, J.,Castaldo, M.,Dekker, N.,Karlsson, U.,Hurt-Camejo, E.
Discovery of Azd2716: A Novel Secreted Phospholipase A2 (Spla2) Inhibitor for the Treatment of Coronary Artery Disease
Acs Med.Chem.Lett., 7:884-, 2016
Cited by
PubMed: 27774123
DOI: 10.1021/ACSMEDCHEMLETT.6B00188
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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