PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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4ZKL	Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog) 分子名称: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 著者 Dolot, R.M, Kaczmarek, R, Seda, A, Krakowiak, A, Baraniak, J, Nawrot, B. 登録日 2015-04-30 公開日 2016-03-02 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A. Int.J.Biol.Macromol., 87, 2016
1NQ0	TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD 分子名称: ARSENIC, Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID 著者 Huber, B.R, Desclozeaux, M, West, B.L, Cunha-Lima, S.T, Nguyen, H.T, Baxter, J.D, Ingraham, H.A, Fletterick, R.J. 登録日 2003-01-20 公開日 2003-04-15 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain Mol.Endocrinol., 17, 2003
4A4V	Ligand binding domain of human PPAR gamma in complex with amorfrutin 2 分子名称: AMORFRUTIN 2, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA 著者 de Groot, J.C, Weidner, C, Krausze, J, Kawamoto, K, Schroeder, F.C, Sauer, S, Buessow, K. 登録日 2011-10-20 公開日 2012-10-03 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor Gamma. J.Med.Chem., 56, 2013
6S35	LSD1/CoREST1 complex with macrocyclic peptide inhibitor 分子名称: ALA-ARG-(D)LYS-MET-GLN-GLU-ALA-ARG-LYS-SER-THR, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, ... 著者 Talibov, V.O, Dobritzsch, D. 登録日 2019-06-24 公開日 2020-02-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1. Acs Omega, 5, 2020
2Q60	Crystal structure of the ligand binding domain of polyandrocarpa misakiensis rxr in tetramer in absence of ligand 分子名称: Retinoid X receptor 著者 Borel, F, De Groot, A, Juillan-Binard, C, De Rosny, E, Laudet, V, Pebay-Peyroula, E, Fontecilla-Camps, J.-C, Ferrer, J.-L. 登録日 2007-06-04 公開日 2008-05-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of the ligand-binding domain of the retinoid X receptor from the ascidian polyandrocarpa misakiensis. Proteins, 74, 2008
1QKM	HUMAN OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH PARTIAL AGONIST GENISTEIN 分子名称: ESTROGEN RECEPTOR BETA, GENISTEIN 著者 Pike, A.C.W, Brzozowski, A.M, Carlquist, M. 登録日 1999-07-27 公開日 2000-07-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist Embo J., 18, 1999
6SQF	Crystal structure of CREBBP bromodomain complexed with LB32A 分子名称: CREB-binding protein, ~{N}-[3-[[5-ethanoyl-2-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]phenyl]carbamoyl]-5-(1-methylpyrazol-3-yl)phenyl]furan-2-carboxamide 著者 Bedi, R.K, Laul, E, Nevado, C, Caflisch, A. 登録日 2019-09-03 公開日 2020-09-30 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.006 Å) 主引用文献 Crystal structure of CREBBP bromodomain complexed with LB32A To Be Published
8CVS	Human PA200-20S proteasome with MG-132 分子名称: INOSITOL HEXAKISPHOSPHATE, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide, Proteasome activator complex subunit 4, ... 著者 Zhao, J. 登録日 2022-05-18 公開日 2022-11-02 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
8KGF	Structure of AmCas12a with crRNA 分子名称: CRISPR-associated endonuclease Cas12a, MAGNESIUM ION, RNA (44-MER) 著者 Feng, Y, Zhang, X, Shi, J, Ma, P, Tang, J, Huang, X. 登録日 2023-08-18 公開日 2024-09-04 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 A novel CRISPR/Cas12a in complex with a crRNA. To Be Published
4YKO	Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y:A32Y:F3Q mutant of human Cellular Retinoic Acid Binding Protein II with Retinal at 1.58 angstrom resolution 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Nosrati, M, Geiger, J. 登録日 2015-03-04 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution. J.Am.Chem.Soc., 138, 2016
6T0U	Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence 分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ... 著者 Wandzik, J.M, Kouba, T, Cusack, S. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
6T0V	Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase) 分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ... 著者 Wandzik, J.M, Kouba, T, Cusack, S. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
4YBU	Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII in complex with Retinal after 24 h incubation and 1 hour UV irradiation at 1.92 angstrom - 1st cycle 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Nosrati, M, Geiger, J.H. 登録日 2015-02-19 公開日 2016-02-24 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.924 Å) 主引用文献 A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution. J.Am.Chem.Soc., 138, 2016
4YCH	Crystal Structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII with Retinal at 1.96 Angstrom - UV irradiated Crystal for 1 hour - 2nd cycle 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Nosrati, M, Geiger, J.H. 登録日 2015-02-20 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution. J.Am.Chem.Soc., 138, 2016
6T0W	Human Influenza B polymerase recycling complex 分子名称: Polymerase PB2, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ... 著者 Wandzik, J.M, Kouba, T, Karuppasamy, M, Cusack, S. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.18 Å) 主引用文献 A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020
5G5P	Structure of the Saccharomyces cerevisiae TREX-2 complex 分子名称: 26S PROTEASOME COMPLEX SUBUNIT SEM1, NUCLEAR MRNA EXPORT PROTEIN SAC3, NUCLEAR MRNA EXPORT PROTEIN THP1 著者 Aibara, S, Bai, X.C, Stewart, M. 登録日 2016-05-26 公開日 2016-11-23 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.3 Å) 主引用文献 The Sac3 Tpr-Like Region in the Saccharomyces Cerevisiae Trex-2 Complex is More Extensive But Independent of the Cid Region J.Struct.Biol., 195, 2016
7VW5	Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold 分子名称: MAGNESIUM ION, RNA-directed RNA polymerase nsP4 著者 Tan, Y.B, Luo, D. 登録日 2021-11-09 公開日 2022-02-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50, 2022
4YE8	The crystal structure of the Y57H mutant of human GlnRS 分子名称: Glutamine--tRNA ligase 著者 Ognjenovic, J, Wu, J, Ling, J, Simonovic, M. 登録日 2015-02-23 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The crystal structure of human GlnRS provides basis for the development of neurological disorders. Nucleic Acids Res., 44, 2016
7VB4	A crystal structure of alphavirus nonstructural protein 4 (nsP4) reveals an intrinsically dynamic RNA-dependent RNA polymerase 分子名称: GLYCEROL, MAGNESIUM ION, RNA-directed RNA polymerase nsP4 著者 Tan, Y.B, Luo, D. 登録日 2021-08-30 公開日 2022-02-16 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Nucleic Acids Res., 50, 2022
4YOS	p107 pocket domain complexed with LIN52 peptide 分子名称: 1,2-ETHANEDIOL, Protein lin-52 homolog, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, ... 著者 Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M. 登録日 2015-03-12 公開日 2015-05-27 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural mechanisms of DREAM complex assembly and regulation. Genes Dev., 29, 2015
1XV9	crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione. 分子名称: (5BETA)-PREGNANE-3,20-DIONE, Orphan nuclear receptor NR1I3, PENTADECANOIC ACID, ... 著者 Xu, R.X, Lambert, M.H, Wisely, B.B, Warren, E.N, Weinert, E.E, Waitt, G.M, Williams, J.D, Moore, L.B, Willson, T.M, Moore, J.T. 登録日 2004-10-27 公開日 2004-12-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer. Mol.Cell, 16, 2004
5G2E	Structure of the Nap1 H2A H2B complex 分子名称: HISTONE H2A TYPE 1, HISTONE H2B 1.1, NUCLEOSOME ASSEMBLY PROTEIN 著者 AguilarGurrieri, C, Larabi, A, Vinayachandran, V, Patel, N.A, Yen, K, Reja, R, Ebong, I.O, Schoehn, G, Robinson, C.V, Pugh, B.F, Panne, D. 登録日 2016-04-07 公開日 2016-08-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (6.7 Å) 主引用文献 Structural Evidence for Nap1-Dependent H2A-H2B Deposition and Nucleosome Assembly. Embo J., 35, 2016
3V3Q	Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate 分子名称: GLYCEROL, Nuclear receptor subfamily 4 group A member 1, SODIUM ION, ... 著者 Zhang, Q, Shi, C, Yang, K, Chen, Y, Zhan, Y, Wu, Q, Lin, T. 登録日 2011-12-14 公開日 2012-09-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK Nat.Chem.Biol., 8, 2012
7VDQ	The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7 分子名称: 2-[[7-[[2-fluoranyl-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]amino]-1,6-naphthyridin-2-yl]-(1-methylpiperidin-4-yl)amino]ethanoic acid, Cyclin-dependent kinase 5 activator 1, p25, ... 著者 Malojcic, G, Clugston, S.L, Daniels, M, Harmange, J.C, Ledeborer, M. 登録日 2021-09-07 公開日 2022-03-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem., 65, 2022
7VDS	The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 24 分子名称: 1,2-ETHANEDIOL, 5-fluoranyl-4-[[2-[(1R)-1-(1-methylpiperidin-4-yl)-1-oxidanyl-ethyl]-1,6-naphthyridin-7-yl]amino]-2-morpholin-4-yl-benzenecarbonitrile, CHLORIDE ION, ... 著者 Malojcic, G, Clugston, S.L, Daniels, M, Harmange, J.C, Ledeborer, M. 登録日 2021-09-07 公開日 2022-03-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem., 65, 2022

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