1NQ0
TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
Summary for 1NQ0
Entry DOI | 10.2210/pdb1nq0/pdb |
Descriptor | Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, ARSENIC, ... (4 entities in total) |
Functional Keywords | thyroid hormone receptor, hormone-growth factor receptor complex, hormone/growth factor receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P10828 |
Total number of polymer chains | 1 |
Total formula weight | 30785.84 |
Authors | Huber, B.R.,Desclozeaux, M.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Baxter, J.D.,Ingraham, H.A.,Fletterick, R.J. (deposition date: 2003-01-20, release date: 2003-04-15, Last modification date: 2024-04-03) |
Primary citation | Huber, B.R.,Desclozeaux, M.,West, B.L.,Cunha-Lima, S.T.,Nguyen, H.T.,Baxter, J.D.,Ingraham, H.A.,Fletterick, R.J. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain Mol.Endocrinol., 17:107-116, 2003 Cited by PubMed: 12511610DOI: 10.1210/me.2002-0097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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