1NQ0

TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4HY A 500

Chain	Residue
A	PHE272
A	HIS435
A	MET442
A	PHE455
A	HOH727
A	ALA279
A	MET310
A	MET313
A	ARG320
A	LEU330
A	ASN331
A	LEU346
A	ILE353

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ARS A 600

Chain	Residue
A	CYS294
A	HOH766

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 601

Chain	Residue
A	CYS434

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 602

Chain	Residue
A	CYS434

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ARS A 603

Chain	Residue
A	GLN205
A	CYS298
A	GLU299
A	ILE302

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 604

Chain	Residue
A	HOH765

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ARS A 605

Chain	Residue
A	CYS388
A	ARG391

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15466465, ECO:0007744|PDB:1Y0X

Chain	Residue	Details
A	ARG282
A	ASN331
A	HIS435

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