7VDQ

The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7

Summary for 7VDQ

Entry DOI	10.2210/pdb7vdq/pdb
Descriptor	Cyclin-dependent-like kinase 5, Cyclin-dependent kinase 5 activator 1, p25, 2-[[7-[[2-fluoranyl-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]amino]-1,6-naphthyridin-2-yl]-(1-methylpiperidin-4-yl)amino]ethanoic acid, ... (4 entities in total)
Functional Keywords	cdk5, p25, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	114287.53
Authors	Malojcic, G.,Clugston, S.L.,Daniels, M.,Harmange, J.C.,Ledeborer, M. (deposition date: 2021-09-07, release date: 2022-03-09, Last modification date: 2023-11-29)
Primary citation	Daniels, M.H.,Malojcic, G.,Clugston, S.L.,Williams, B.,Coeffet-Le Gal, M.,Pan-Zhou, X.R.,Venkatachalan, S.,Harmange, J.C.,Ledeboer, M. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem., 65:3575-3596, 2022 Cited by PubMed: 35143203 DOI: 10.1021/acs.jmedchem.1c02069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation