7VDQ

The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cyclin-dependent-like kinase 5	polymer	292	33306.3	2	UniProt (Q00535) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 5
2	C, D (C, D)	Cyclin-dependent kinase 5 activator 1, p25	polymer	209	23331.9	2	UniProt (Q15078) Pfam (PF03261)	Homo sapiens (Human)	p25,Tau protein kinase II 23 kDa subunit,p23
3	E, F (A, B)	2-[[7-[[2-fluoranyl-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]amino]-1,6-naphthyridin-2-yl]-(1-methylpiperidin-4-yl)amino]ethanoic acid	non-polymer		505.5	2	Chemie (64V)
4	G, H, I (A, B, C)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B: 2 - 292 (UniProt: Q00535)

PDB	External Database	Details
Ser 1	-	expression tag

C, D: 100 - 307 (UniProt: Q15078)

PDB	External Database	Details
Met 99	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	113276.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1011.1
All*	Total formula weight	114287.5

*Water molecules are not included.