7VDQ
The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 7
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cyclin-dependent-like kinase 5 | polymer | 292 | 33306.3 | 2 | UniProt (Q00535) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 5 |
2 | C, D | Cyclin-dependent kinase 5 activator 1, p25 | polymer | 209 | 23331.9 | 2 | UniProt (Q15078) Pfam (PF03261) In PDB | Homo sapiens (Human) | p25,Tau protein kinase II 23 kDa subunit,p23 |
3 | A, B | 2-[[7-[[2-fluoranyl-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]amino]-1,6-naphthyridin-2-yl]-(1-methylpiperidin-4-yl)amino]ethanoic acid | non-polymer | 505.5 | 2 | Chemie (64V) | |||
4 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 292 (UniProt: Q00535)
C, D: 100 - 307 (UniProt: Q15078)
PDB | External Database | Details |
---|---|---|
Ser 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 99 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 113276.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1011.1 | |
All* | Total formula weight | 114287.5 |