6S35

LSD1/CoREST1 complex with macrocyclic peptide inhibitor

Summary for 6S35

• Entry DOI: 10.2210/pdb6s35/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, ALA-ARG-(D)LYS-MET-GLN-GLU-ALA-ARG-LYS-SER-THR, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, flavoprotein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 96818.09

Authors

Talibov, V.O.,Dobritzsch, D. (deposition date: 2019-06-24, release date: 2020-02-26, Last modification date: 2024-01-24)

• Primary citation: Yang, J.,Talibov, V.O.,Peintner, S.,Rhee, C.,Poongavanam, V.,Geitmann, M.,Sebastiano, M.R.,Simon, B.,Hennig, J.,Dobritzsch, D.,Danielson, U.H.,Kihlberg, J.; Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1.; Acs Omega, 5:3979-3995, 2020; PubMed: 32149225; DOI: 10.1021/acsomega.9b03493

Experimental method

X-RAY DIFFRACTION (3.1 Å)