6S35
LSD1/CoREST1 complex with macrocyclic peptide inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 666 | 74065.7 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2 |
| 2 | B (B) | REST corepressor 1 | polymer | 182 | 20658.3 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | Homo sapiens (Human) | Protein CoREST |
| 3 | C (C) | ALA-ARG-(D)LYS-MET-GLN-GLU-ALA-ARG-LYS-SER-THR | polymer | 11 | 1308.5 | 1 | synthetic construct | ||
| 4 | D (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) |
Sequence modifications
A: 172 - 833 (UniProt: O60341)
B: 308 - 485 (UniProt: Q9UKL0)
| PDB | External Database | Details |
|---|---|---|
| Gly 168 | - | expression tag |
| Ser 169 | - | expression tag |
| His 170 | - | expression tag |
| Met 171 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 304 | - | expression tag |
| Ser 305 | - | expression tag |
| His 306 | - | expression tag |
| Met 307 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 96032.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 785.5 | |
| All* | Total formula weight | 96818.1 |
