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6S35

LSD1/CoREST1 complex with macrocyclic peptide inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
A0016491molecular_functionoxidoreductase activity
A0050660molecular_functionflavin adenine dinucleotide binding
Functional Information from PDB Data
site_idAC1
Number of Residues32
Detailsbinding site for residue FAD A 901
ChainResidue
AGLY285
AGLY314
AGLY315
AARG316
AVAL317
ALEU329
AGLY330
AALA331
AMET332
AVAL333
AVAL590
ASER286
ATHR624
ALEU625
APRO626
AVAL637
ATRP751
ATRP756
ASER760
ATYR761
AGLY800
AGLU801
AGLY287
ATHR810
AVAL811
AALA814
AVAL288
ASER289
ALEU307
AGLU308
AALA309
AARG310

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER460
AGLU308
AARG310
AARG316
AMET332
AGLU801
ATHR810

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS466
ALYS433
ALYS436

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER611

site_idSWS_FT_FI4
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS442
ALYS469

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020
ChainResidueDetails
ALYS503

227561

PDB entries from 2024-11-20

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