1XV9

crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.

Summary for 1XV9

DescriptorRetinoic acid receptor RXR-alpha, Orphan nuclear receptor NR1I3, nuclear receptor coactivator 1 isoform 1, ... (6 entities in total)
Functional Keywordscar, rxr, src1, pregnanedione, dna binding protein
Biological sourceHomo sapiens (human)
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Cellular locationNucleus Q14994 P19793
Total number of polymer chains8
Total molecular weight116914.26
Authors
Xu, R.X.,Lambert, M.H.,Wisely, B.B.,Warren, E.N.,Weinert, E.E.,Waitt, G.M.,Williams, J.D.,Moore, L.B.,Willson, T.M.,Moore, J.T. (deposition date: 2004-10-27, release date: 2004-12-28, Last modification date: 2016-11-30)
Primary citation
Xu, R.X.,Lambert, M.H.,Wisely, B.B.,Warren, E.N.,Weinert, E.E.,Waitt, G.M.,Williams, J.D.,Collins, J.L.,Moore, L.B.,Willson, T.M.,Moore, J.T.
A Structural Basis for Constitutive Activity in the Human CAR/RXRalpha Heterodimer.
Mol.Cell, 16:919-928, 2004
PubMed: 15610735 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2004.11.042
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239323.7%4.7%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1xv9
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Molmil generated image of 1xv9
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More Biological unit images

Molmil generated image of 1xv9
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Molmil generated image of 1xv9
rotated about x axis by 90°
Molmil generated image of 1xv9
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (1xv9.pdb1.gz [84.58 KB])
Coordinate files for Biological unit (1xv9.pdb2.gz [87.43 KB])