1XV9
crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Retinoic acid receptor RXR-alpha | polymer | 236 | 26509.7 | 2 | UniProt (P19793) Pfam (PF00104) In PDB | Homo sapiens (human) | Retinoid X receptor alpha |
| 2 | B, D | Orphan nuclear receptor NR1I3 | polymer | 246 | 28279.0 | 2 | UniProt (Q14994) Pfam (PF00104) In PDB | Homo sapiens (human) | Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67 |
| 3 | E, F, G, H | nuclear receptor coactivator 1 isoform 1 | polymer | 13 | 1633.9 | 4 | GenBank (22538455) UniProt (by SIFTS) (Q15788) In PDB | Homo sapiens | |
| 4 | A, C | PENTADECANOIC ACID | non-polymer | 242.4 | 2 | Chemie (F15) | |||
| 5 | D | (5BETA)-PREGNANE-3,20-DIONE | non-polymer | 316.5 | 1 | Chemie (CI2) | |||
| 6 | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
B, D: 103 - 348 (UniProt: Q14994)
| PDB | External Database | Details |
|---|---|---|
| - | Val 232 | deletion |
| - | Ser 233 | deletion |
| - | Pro 234 | deletion |
| - | Thr 235 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 116113.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 801.3 | |
| All* | Total formula weight | 116914.3 |
