7VDS

The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 24

Summary for 7VDS

Entry DOI	10.2210/pdb7vds/pdb
Descriptor	Cyclin-dependent-like kinase 5, p25, Cyclin-dependent kinase 5 activator 1, 5-fluoranyl-4-[[2-[(1R)-1-(1-methylpiperidin-4-yl)-1-oxidanyl-ethyl]-1,6-naphthyridin-7-yl]amino]-2-morpholin-4-yl-benzenecarbonitrile, ... (7 entities in total)
Functional Keywords	cdk5, p25, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	116418.73
Authors	Malojcic, G.,Clugston, S.L.,Daniels, M.,Harmange, J.C.,Ledeborer, M. (deposition date: 2021-09-07, release date: 2022-03-09, Last modification date: 2023-11-29)
Primary citation	Daniels, M.H.,Malojcic, G.,Clugston, S.L.,Williams, B.,Coeffet-Le Gal, M.,Pan-Zhou, X.R.,Venkatachalan, S.,Harmange, J.C.,Ledeboer, M. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J.Med.Chem., 65:3575-3596, 2022 Cited by PubMed: 35143203 DOI: 10.1021/acs.jmedchem.1c02069 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.05 Å)

Structure validation