7VDS

The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 24

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
A	0001764	biological_process	neuron migration
A	0002039	molecular_function	p53 binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
A	0005176	molecular_function	ErbB-2 class receptor binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007268	biological_process	chemical synaptic transmission
A	0007399	biological_process	nervous system development
A	0007409	biological_process	axonogenesis
A	0007416	biological_process	synapse assembly
A	0008017	molecular_function	microtubule binding
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0016079	biological_process	synaptic vesicle exocytosis
A	0016241	biological_process	regulation of macroautophagy
A	0016301	molecular_function	kinase activity
A	0016533	cellular_component	protein kinase 5 complex
A	0016740	molecular_function	transferase activity
A	0030027	cellular_component	lamellipodium
A	0030036	biological_process	actin cytoskeleton organization
A	0030054	cellular_component	cell junction
A	0030175	cellular_component	filopodium
A	0030182	biological_process	neuron differentiation
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0030547	molecular_function	signaling receptor inhibitor activity
A	0030549	molecular_function	acetylcholine receptor activator activity
A	0031175	biological_process	neuron projection development
A	0031594	cellular_component	neuromuscular junction
A	0035255	molecular_function	ionotropic glutamate receptor binding
A	0042981	biological_process	regulation of apoptotic process
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043125	molecular_function	ErbB-3 class receptor binding
A	0043204	cellular_component	perikaryon
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0045202	cellular_component	synapse
A	0045861	biological_process	negative regulation of proteolysis
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0048156	molecular_function	tau protein binding
A	0048167	biological_process	regulation of synaptic plasticity
A	0048488	biological_process	synaptic vesicle endocytosis
A	0048489	biological_process	synaptic vesicle transport
A	0048511	biological_process	rhythmic process
A	0048675	biological_process	axon extension
A	0048709	biological_process	oligodendrocyte differentiation
A	0050321	molecular_function	tau-protein kinase activity
A	0051301	biological_process	cell division
A	0051402	biological_process	neuron apoptotic process
A	0051649	biological_process	establishment of localization in cell
A	0051726	biological_process	regulation of cell cycle
A	0051879	molecular_function	Hsp90 protein binding
A	0051966	biological_process	regulation of synaptic transmission, glutamatergic
A	0061001	biological_process	regulation of dendritic spine morphogenesis
A	0098793	cellular_component	presynapse
A	0099533	biological_process	positive regulation of presynaptic cytosolic calcium concentration
A	0106310	molecular_function	protein serine kinase activity
A	1901987	biological_process	regulation of cell cycle phase transition
A	1903076	biological_process	regulation of protein localization to plasma membrane
A	1903234	biological_process	negative regulation of calcium ion-dependent exocytosis of neurotransmitter
A	1903421	biological_process	regulation of synaptic vesicle recycling
A	1904646	biological_process	cellular response to amyloid-beta
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000307	cellular_component	cyclin-dependent protein kinase holoenzyme complex
B	0001764	biological_process	neuron migration
B	0002039	molecular_function	p53 binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004693	molecular_function	cyclin-dependent protein serine/threonine kinase activity
B	0005176	molecular_function	ErbB-2 class receptor binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0007268	biological_process	chemical synaptic transmission
B	0007399	biological_process	nervous system development
B	0007409	biological_process	axonogenesis
B	0007416	biological_process	synapse assembly
B	0008017	molecular_function	microtubule binding
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0016079	biological_process	synaptic vesicle exocytosis
B	0016241	biological_process	regulation of macroautophagy
B	0016301	molecular_function	kinase activity
B	0016533	cellular_component	protein kinase 5 complex
B	0016740	molecular_function	transferase activity
B	0030027	cellular_component	lamellipodium
B	0030036	biological_process	actin cytoskeleton organization
B	0030054	cellular_component	cell junction
B	0030175	cellular_component	filopodium
B	0030182	biological_process	neuron differentiation
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0030547	molecular_function	signaling receptor inhibitor activity
B	0030549	molecular_function	acetylcholine receptor activator activity
B	0031175	biological_process	neuron projection development
B	0031594	cellular_component	neuromuscular junction
B	0035255	molecular_function	ionotropic glutamate receptor binding
B	0042981	biological_process	regulation of apoptotic process
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043125	molecular_function	ErbB-3 class receptor binding
B	0043204	cellular_component	perikaryon
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0045202	cellular_component	synapse
B	0045861	biological_process	negative regulation of proteolysis
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0048156	molecular_function	tau protein binding
B	0048167	biological_process	regulation of synaptic plasticity
B	0048488	biological_process	synaptic vesicle endocytosis
B	0048489	biological_process	synaptic vesicle transport
B	0048511	biological_process	rhythmic process
B	0048675	biological_process	axon extension
B	0048709	biological_process	oligodendrocyte differentiation
B	0050321	molecular_function	tau-protein kinase activity
B	0051301	biological_process	cell division
B	0051402	biological_process	neuron apoptotic process
B	0051649	biological_process	establishment of localization in cell
B	0051726	biological_process	regulation of cell cycle
B	0051879	molecular_function	Hsp90 protein binding
B	0051966	biological_process	regulation of synaptic transmission, glutamatergic
B	0061001	biological_process	regulation of dendritic spine morphogenesis
B	0098793	cellular_component	presynapse
B	0099533	biological_process	positive regulation of presynaptic cytosolic calcium concentration
B	0106310	molecular_function	protein serine kinase activity
B	1901987	biological_process	regulation of cell cycle phase transition
B	1903076	biological_process	regulation of protein localization to plasma membrane
B	1903234	biological_process	negative regulation of calcium ion-dependent exocytosis of neurotransmitter
B	1903421	biological_process	regulation of synaptic vesicle recycling
B	1904646	biological_process	cellular response to amyloid-beta
C	0016533	cellular_component	protein kinase 5 complex
C	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity
D	0016533	cellular_component	protein kinase 5 complex
D	0061575	molecular_function	cyclin-dependent protein serine/threonine kinase activator activity

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGTVFkAknrethei..........VALK

Chain	Residue	Details
A	ILE10-LYS33

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI

Chain	Residue	Details
A	VAL122-ILE134

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	282
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1, EPHA4 and FYN","evidences":[{"source":"PubMed","id":"15689152","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17143272","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10500146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---