7VDS
The structure of cyclin-dependent kinase 5 (CDK5) in complex with p25 and Compound 24
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Cyclin-dependent-like kinase 5, p25 | polymer | 292 | 33306.3 | 2 | UniProt (Q00535) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 5 |
| 2 | C, D | Cyclin-dependent kinase 5 activator 1 | polymer | 209 | 23331.9 | 2 | UniProt (Q15078) Pfam (PF03261) In PDB | Homo sapiens (Human) | |
| 3 | A | 5-fluoranyl-4-[[2-[(1R)-1-(1-methylpiperidin-4-yl)-1-oxidanyl-ethyl]-1,6-naphthyridin-7-yl]amino]-2-morpholin-4-yl-benzenecarbonitrile | non-polymer | 490.6 | 1 | Chemie (61U) | |||
| 4 | A, C | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | B, C, A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 20 | Chemie (EDO) | |||
| 6 | A, C | CHLORIDE ION | non-polymer | 35.5 | 19 | Chemie (CL) | |||
| 7 | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 292 (UniProt: Q00535)
C, D: 100 - 307 (UniProt: Q15078)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 99 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 113276.4 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 3142.3 | |
| All* | Total formula weight | 116418.7 |
