4ZKL
Crystal structure of human histidine triad nucleotide-binding protein 1 (hHINT1) complexed with JB419 (AP4A analog)
Summary for 4ZKL
Entry DOI | 10.2210/pdb4zkl/pdb |
Related | 1KPC 3TW2 |
Descriptor | Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[2-[[(2S)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-sulfanyl-phosphoryl]oxy-2-oxidanyl-propoxy]-sulfanyl-phosphoryl]oxyethyl]oxolane-3,4-diol, ... (4 entities in total) |
Functional Keywords | hint, hit, hydrolase, phosphoramidase, complex, ap4a analog |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P49773 |
Total number of polymer chains | 4 |
Total formula weight | 56786.83 |
Authors | Dolot, R.M.,Kaczmarek, R.,Seda, A.,Krakowiak, A.,Baraniak, J.,Nawrot, B. (deposition date: 2015-04-30, release date: 2016-03-02, Last modification date: 2024-01-10) |
Primary citation | Dolot, R.,Kaczmarek, R.,Seda, A.,Krakowiak, A.,Baraniak, J.,Nawrot, B. Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A. Int.J.Biol.Macromol., 87:62-69, 2016 Cited by PubMed: 26905466DOI: 10.1016/j.ijbiomac.2016.02.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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