7CRQ
| NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | 登録日 | 2020-08-14 | 公開日 | 2020-10-21 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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7CRP
| NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode) | 分子名称: | DNA (168-MER), Histone H2A, Histone H2B, ... | 著者 | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | 登録日 | 2020-08-14 | 公開日 | 2020-10-21 | 最終更新日 | 2021-03-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. Nature, 590, 2021
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5WFC
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5WFD
| Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK126 | 分子名称: | 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... | 著者 | Bratkowski, M.A, Liu, X. | 登録日 | 2017-07-11 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.654 Å) | 主引用文献 | An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
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5WF7
| Chaetomium thermophilum Polycomb Repressive Complex 2 bound to GSK126 | 分子名称: | 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... | 著者 | Bratkowski, M.A, Liu, X. | 登録日 | 2017-07-11 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
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5WG6
| Human Polycomb Repressive Complex 2 in complex with GSK126 inhibitor | 分子名称: | 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine N-methyltransferase EZH2,Polycomb protein SUZ12 (E.C.2.1.1.43) chimera, Polycomb protein EED, ... | 著者 | Bratkowski, M.A, Liu, X. | 登録日 | 2017-07-13 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.901 Å) | 主引用文献 | An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
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5F6L
| The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L | 分子名称: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Li, Y, Lei, M, Chen, Y. | 登録日 | 2015-12-06 | 公開日 | 2016-02-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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5F6K
| Crystal structure of the MLL3-Ash2L-RbBP5 complex | 分子名称: | Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Li, Y, Lei, M, Chen, Y. | 登録日 | 2015-12-06 | 公開日 | 2016-02-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.411 Å) | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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7W6L
| The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide | 分子名称: | Histone H3.3C, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ... | 著者 | Zhao, L, Li, Y, Chen, Y. | 登録日 | 2021-12-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W6A
| Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex | 分子名称: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Zhao, L, Li, Y, Chen, Y. | 登録日 | 2021-12-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W6I
| The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide | 分子名称: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | 著者 | Zhao, L, Li, Y, Chen, Y. | 登録日 | 2021-12-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W6J
| The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide | 分子名称: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | 著者 | Zhao, L, Li, Y, Chen, Y. | 登録日 | 2021-12-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W67
| The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide | 分子名称: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | 著者 | Zhao, L, Li, Y, Chen, Y. | 登録日 | 2021-12-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | 主引用文献 | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7XPX
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6PWW
| Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome | 分子名称: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | 登録日 | 2019-07-23 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
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5HYN
| Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide | 分子名称: | H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ... | 著者 | Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J. | 登録日 | 2016-02-01 | 公開日 | 2016-05-11 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2. Nat Commun, 7, 2016
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5HQ2
| Structural model of Set8 histone H4 Lys20 methyltransferase bound to nucleosome core particle | 分子名称: | DNA (149-MER), Guanine nucleotide exchange factor SRM1, Histone H2A, ... | 著者 | Tavarekere, G, McGinty, R.K, Tan, S. | 登録日 | 2016-01-21 | 公開日 | 2016-03-23 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (4.5 Å) | 主引用文献 | Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate. J.Mol.Biol., 428, 2016
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5IJ7
| Structure of Hs/AcPRC2 in complex with a pyridone inhibitor | 分子名称: | 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... | 著者 | Gajiwala, K.S, Brooun, A, Deng, Y.-L, Liu, W. | 登録日 | 2016-03-01 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance. Nat Commun, 7, 2016
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6KIZ
| Cryo-EM structure of human MLL1-NCP complex, binding mode2 | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Huang, J, Xue, H, Yao, T. | 登録日 | 2019-07-20 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIV
| Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Huang, J, Xue, H, Yao, T. | 登録日 | 2019-07-20 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6KIU
| Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | 分子名称: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | 著者 | Huang, J, Xue, H, Yao, T. | 登録日 | 2019-07-20 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6UH5
| Structural basis of COMPASS eCM recognition of the H2Bub nucleosome | 分子名称: | Bre2, DNA (146-MER), H3 N-terminus, ... | 著者 | Hsu, P.L, Shi, H, Zheng, N. | 登録日 | 2019-09-26 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS. Mol.Cell, 76, 2019
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6KIW
| Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) | 分子名称: | DNA (144-MER), DNA (145-MER), Histone H2A, ... | 著者 | Huang, J, Xue, H, Yao, T. | 登録日 | 2019-07-20 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases. Nature, 573, 2019
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6VEN
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6UGM
| Structural basis of COMPASS eCM recognition of an unmodified nucleosome | 分子名称: | Bre2, DNA (146-MER), H3 N-terminus, ... | 著者 | Hsu, P.L, Shi, H, Zheng, N. | 登録日 | 2019-09-26 | 公開日 | 2019-11-20 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS. Mol.Cell, 76, 2019
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