5WFD

Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK126

Summary for 5WFD

• Entry DOI: 10.2210/pdb5wfd/pdb
• Related: 5WF7 5WFC
• Descriptor: Polycomb Protein EED, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ZINC ION, ... (4 entities in total)
• Functional Keywords: transferase, inhibitor, complex, epigenetics, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719); More
• Total number of polymer chains: 2
• Total formula weight: 173872.98

Authors

Bratkowski, M.A.,Liu, X. (deposition date: 2017-07-11, release date: 2018-06-27, Last modification date: 2023-10-04)

• Primary citation: Bratkowski, M.,Yang, X.,Liu, X.; An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.; Sci Rep, 8:9092-9092, 2018; PubMed: 29904056; DOI: 10.1038/s41598-018-27175-w

Experimental method

X-RAY DIFFRACTION (2.654 Å)