6PWW

Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome

Summary for 6PWW

• Entry DOI: 10.2210/pdb6pww/pdb
• EMDB information: 20513
• Descriptor: Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... (11 entities in total)
• Functional Keywords: mixed-lineage leukemia, mll1, nucleosome, histone h3 lys4 methyltransferase, rbbp5, wdr5, histone binding-dna binding-dna complex, histone binding/dna binding/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 13
• Total formula weight: 317838.20

Authors

Park, S.H.,Ayoub, A.,Lee, Y.T.,Xu, J.,Zhang, W.,Zhang, B.,Zhang, Y.,Cianfrocco, M.A.,Su, M.,Dou, Y.,Cho, U. (deposition date: 2019-07-23, release date: 2019-12-18, Last modification date: 2024-03-20)

• Primary citation: Park, S.H.,Ayoub, A.,Lee, Y.T.,Xu, J.,Kim, H.,Zheng, W.,Zhang, B.,Sha, L.,An, S.,Zhang, Y.,Cianfrocco, M.A.,Su, M.,Dou, Y.,Cho, U.S.; Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.; Nat Commun, 10:5540-5540, 2019; PubMed: 31804488; DOI: 10.1038/s41467-019-13550-2

Experimental method

ELECTRON MICROSCOPY (4.4 Å)