6PWW
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000976 | molecular_function | transcription cis-regulatory region binding |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005730 | cellular_component | nucleolus |
A | 0006325 | biological_process | chromatin organization |
A | 0006974 | biological_process | DNA damage response |
A | 0035097 | cellular_component | histone methyltransferase complex |
A | 0042393 | molecular_function | histone binding |
A | 0043627 | biological_process | response to estrogen |
A | 0044665 | cellular_component | MLL1/2 complex |
A | 0044666 | cellular_component | MLL3/4 complex |
A | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
A | 0048188 | cellular_component | Set1C/COMPASS complex |
A | 0071339 | cellular_component | MLL1 complex |
B | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
B | 0000123 | cellular_component | histone acetyltransferase complex |
B | 0001501 | biological_process | skeletal system development |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0006094 | biological_process | gluconeogenesis |
B | 0006325 | biological_process | chromatin organization |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
B | 0035064 | molecular_function | methylated histone binding |
B | 0035097 | cellular_component | histone methyltransferase complex |
B | 0042393 | molecular_function | histone binding |
B | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
B | 0044545 | cellular_component | NSL complex |
B | 0044665 | cellular_component | MLL1/2 complex |
B | 0044666 | cellular_component | MLL3/4 complex |
B | 0045722 | biological_process | positive regulation of gluconeogenesis |
B | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
B | 0045995 | biological_process | regulation of embryonic development |
B | 0048188 | cellular_component | Set1C/COMPASS complex |
B | 0051302 | biological_process | regulation of cell division |
B | 0051726 | biological_process | regulation of cell cycle |
B | 0071339 | cellular_component | MLL1 complex |
B | 0072686 | cellular_component | mitotic spindle |
B | 0090043 | biological_process | regulation of tubulin deacetylation |
B | 0140672 | cellular_component | ATAC complex |
G | 0000786 | cellular_component | nucleosome |
G | 0003677 | molecular_function | DNA binding |
G | 0005515 | molecular_function | protein binding |
G | 0005634 | cellular_component | nucleus |
G | 0005654 | cellular_component | nucleoplasm |
G | 0005694 | cellular_component | chromosome |
G | 0030527 | molecular_function | structural constituent of chromatin |
G | 0046982 | molecular_function | protein heterodimerization activity |
H | 0000786 | cellular_component | nucleosome |
H | 0003677 | molecular_function | DNA binding |
H | 0005515 | molecular_function | protein binding |
H | 0005634 | cellular_component | nucleus |
H | 0005694 | cellular_component | chromosome |
H | 0006334 | biological_process | nucleosome assembly |
H | 0030527 | molecular_function | structural constituent of chromatin |
H | 0046982 | molecular_function | protein heterodimerization activity |
I | 0000786 | cellular_component | nucleosome |
I | 0003677 | molecular_function | DNA binding |
I | 0005634 | cellular_component | nucleus |
I | 0005694 | cellular_component | chromosome |
I | 0030527 | molecular_function | structural constituent of chromatin |
I | 0046982 | molecular_function | protein heterodimerization activity |
J | 0000786 | cellular_component | nucleosome |
J | 0003677 | molecular_function | DNA binding |
J | 0005515 | molecular_function | protein binding |
J | 0005634 | cellular_component | nucleus |
J | 0005694 | cellular_component | chromosome |
J | 0030527 | molecular_function | structural constituent of chromatin |
J | 0046982 | molecular_function | protein heterodimerization activity |
K | 0000786 | cellular_component | nucleosome |
K | 0003677 | molecular_function | DNA binding |
K | 0005515 | molecular_function | protein binding |
K | 0005634 | cellular_component | nucleus |
K | 0005654 | cellular_component | nucleoplasm |
K | 0005694 | cellular_component | chromosome |
K | 0030527 | molecular_function | structural constituent of chromatin |
K | 0046982 | molecular_function | protein heterodimerization activity |
L | 0000786 | cellular_component | nucleosome |
L | 0003677 | molecular_function | DNA binding |
L | 0005515 | molecular_function | protein binding |
L | 0005634 | cellular_component | nucleus |
L | 0005694 | cellular_component | chromosome |
L | 0006334 | biological_process | nucleosome assembly |
L | 0030527 | molecular_function | structural constituent of chromatin |
L | 0046982 | molecular_function | protein heterodimerization activity |
M | 0000786 | cellular_component | nucleosome |
M | 0003677 | molecular_function | DNA binding |
M | 0005634 | cellular_component | nucleus |
M | 0005694 | cellular_component | chromosome |
M | 0030527 | molecular_function | structural constituent of chromatin |
M | 0046982 | molecular_function | protein heterodimerization activity |
N | 0000786 | cellular_component | nucleosome |
N | 0003677 | molecular_function | DNA binding |
N | 0005515 | molecular_function | protein binding |
N | 0005634 | cellular_component | nucleus |
N | 0005694 | cellular_component | chromosome |
N | 0030527 | molecular_function | structural constituent of chromatin |
N | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue SAH C 4001 |
Chain | Residue |
C | ILE3838 |
C | HIS3907 |
C | TYR3944 |
C | LEU3955 |
C | PRO3956 |
C | CYS3957 |
C | ASN3958 |
C | LEU3968 |
C | HIS3839 |
C | GLY3840 |
C | ARG3841 |
C | TYR3883 |
C | ARG3903 |
C | PHE3904 |
C | ILE3905 |
C | ASN3906 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN C 4002 |
Chain | Residue |
C | SER3908 |
C | CYS3909 |
C | CYS3957 |
C | CYS3959 |
C | CYS3964 |
Functional Information from PROSITE/UniProt
site_id | PS00046 |
Number of Residues | 7 |
Details | HISTONE_H2A Histone H2A signature. AGLqFPV |
Chain | Residue | Details |
I | ALA21-VAL27 |
site_id | PS00047 |
Number of Residues | 5 |
Details | HISTONE_H4 Histone H4 signature. GAKRH |
Chain | Residue | Details |
H | GLY14-HIS18 |
site_id | PS00322 |
Number of Residues | 7 |
Details | HISTONE_H3_1 Histone H3 signature 1. KAPRKQL |
Chain | Residue | Details |
G | LYS14-LEU20 |
site_id | PS00357 |
Number of Residues | 23 |
Details | HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG |
Chain | Residue | Details |
J | ARG89-GLY111 |
site_id | PS00678 |
Number of Residues | 15 |
Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV |
Chain | Residue | Details |
B | LEU102-VAL116 | |
B | ILE144-VAL158 | |
B | ILE186-THR200 | |
B | ILE274-LEU288 |
site_id | PS00959 |
Number of Residues | 9 |
Details | HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI |
Chain | Residue | Details |
G | PRO66-ILE74 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0C1H4 |
Chain | Residue | Details |
J | LYS2 | |
J | LYS9 | |
J | LYS12 | |
J | LYS17 | |
N | LYS2 | |
N | LYS9 | |
N | LYS12 | |
N | LYS17 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:12757711 |
Chain | Residue | Details |
J | SER11 | |
N | SER11 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807 |
Chain | Residue | Details |
J | SER109 | |
N | SER109 | |
M | LYS9 | |
M | LYS95 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0C1H4 |
Chain | Residue | Details |
J | LYS117 | |
M | LYS36 | |
N | LYS117 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P0C0S8 |
Chain | Residue | Details |
I | LYS74 | |
I | LYS75 | |
M | LYS74 | |
M | LYS75 | |
L | LYS8 | |
L | LYS16 | |
L | LYS44 | |
L | LYS79 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N5-methylglutamine => ECO:0000250 |
Chain | Residue | Details |
I | GLN104 | |
M | GLN104 | |
L | LYS12 | |
L | LYS20 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P0C0S8 |
Chain | Residue | Details |
I | LYS118 | |
M | LYS118 | |
L | LYS31 | |
L | LYS91 |
site_id | SWS_FT_FI8 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250 |
Chain | Residue | Details |
I | LYS13 | |
L | SER47 | |
I | LYS15 | |
I | LYS119 | |
M | LYS13 | |
M | LYS15 | |
M | LYS119 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805 |
Chain | Residue | Details |
H | TYR51 | |
H | TYR88 | |
L | TYR51 | |
L | TYR88 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805 |
Chain | Residue | Details |
H | LYS59 | |
K | LYS64 | |
L | LYS59 | |
G | LYS27 | |
G | LYS36 | |
G | LYS64 | |
K | LYS18 | |
K | LYS23 | |
K | LYS27 | |
K | LYS36 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805 |
Chain | Residue | Details |
H | LYS77 | |
L | LYS77 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805 |
Chain | Residue | Details |
H | LYS31 | |
L | LYS31 |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805 |
Chain | Residue | Details |
G | LYS37 | |
H | LYS91 | |
L | LYS91 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
G | TYR41 | |
K | TYR41 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228 |
Chain | Residue | Details |
G | LYS56 | |
G | LYS79 | |
K | LYS56 | |
K | LYS79 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
G | SER57 | |
K | SER57 |
site_id | SWS_FT_FI17 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
G | THR80 | |
G | THR107 | |
K | THR80 | |
K | THR107 |
site_id | SWS_FT_FI18 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243 |
Chain | Residue | Details |
G | SER86 | |
K | SER86 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
G | LYS115 | |
K | LYS115 |
site_id | SWS_FT_FI20 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
G | LYS122 | |
K | LYS122 |
site_id | SWS_FT_FI21 |
Number of Residues | 2 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3 |
Chain | Residue | Details |
G | CYS110 | |
K | CYS110 |