7W67

The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide

Summary for 7W67

• Entry DOI: 10.2210/pdb7w67/pdb
• Descriptor: Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... (7 entities in total)
• Functional Keywords: mll family methyltransferases, product specificity, f/y switch, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 43592.88

Authors

Zhao, L.,Li, Y.,Chen, Y. (deposition date: 2021-12-01, release date: 2022-09-07, Last modification date: 2023-11-29)

• Primary citation: Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y.; Structural basis for product specificities of MLL family methyltransferases.; Mol.Cell, 82:3810-3825.e8, 2022; PubMed: 36108631; DOI: 10.1016/j.molcel.2022.08.022

Experimental method

X-RAY DIFFRACTION (2.194 Å)