7W67
The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0048188 | cellular_component | Set1C/COMPASS complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26886794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26886794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26886794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16990798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19187761","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W5Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W5Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F6L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-methylcysteine; by autocatalysis","evidences":[{"source":"PubMed","id":"24235145","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by HASPIN","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"5-glutamyl serotonin; alternate","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"UniProtKB","id":"P68431","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5; alternate","evidences":[{"source":"UniProtKB","id":"P68433","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
