7W67
The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Set1/Ash2 histone methyltransferase complex subunit ASH2 | polymer | 184 | 20597.4 | 1 | UniProt (Q9UBL3) Pfam (PF00622) In PDB | Homo sapiens (human) | ASH2-like protein |
2 | C | Histone-lysine N-methyltransferase 2A | polymer | 158 | 18227.1 | 1 | UniProt (Q03164) Pfam (PF00856) In PDB | Homo sapiens (human) | Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Cysteine methyltransferase KMT2A,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX |
3 | F | Retinoblastoma-binding protein 5 | polymer | 27 | 3255.3 | 1 | UniProt (Q15291) In PDB | Homo sapiens (human) | RBBP-5,Retinoblastoma-binding protein RBQ-3 |
4 | M | Histone H3.3C | polymer | 9 | 1063.3 | 1 | UniProt (Q6NXT2) In PDB | Homo sapiens | H3K4me0 peptide |
5 | C | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
6 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
7 | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A: 286 - 438 (UniProt: Q9UBL3)
A: 445 - 504 (UniProt: Q9UBL3)
C: 3813 - 3970 (UniProt: Q03164)
PDB | External Database | Details |
---|---|---|
Ser 285 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ile 439 | - | linker |
Ser 440 | - | linker |
Gly 441 | - | linker |
Arg 442 | - | linker |
Gly 443 | - | linker |
Ser 444 | - | linker |
PDB | External Database | Details |
---|---|---|
Ile 3861 | Asn 3861 | engineered mutation |
Leu 3867 | Gln 3867 | engineered mutation |
Ser 3882 | - | insertion |
Ser 3883 | Cys 3882 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 43143.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 449.8 | |
All* | Total formula weight | 43592.9 |