5WFC
Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK343
Summary for 5WFC
| Entry DOI | 10.2210/pdb5wfc/pdb |
| Related | 5WF7 |
| Descriptor | Polycomb Protein EED, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, Histone H3.1, ... (6 entities in total) |
| Functional Keywords | transferase, inhibitor, complex, epigenetics, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) More |
| Total number of polymer chains | 3 |
| Total formula weight | 175034.35 |
| Authors | Bratkowski, M.A.,Liu, X. (deposition date: 2017-07-11, release date: 2018-06-27, Last modification date: 2023-10-04) |
| Primary citation | Bratkowski, M.,Yang, X.,Liu, X. An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8:9092-9092, 2018 Cited by PubMed: 29904056DOI: 10.1038/s41598-018-27175-w PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.282 Å) |
Structure validation
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