5WFC
Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK343
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Polycomb Protein EED | polymer | 605 | 66021.4 | 1 | UniProt (G0S8H7) Pfam (PF00400) Pfam (PF22038) In PDB | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | |
2 | B | Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera | polymer | 936 | 106801.7 | 1 | UniProt (G0SDW4) UniProt (G0RYC6) Pfam (PF18601) Pfam (PF18600) Pfam (PF21509) Pfam (PF00856) Pfam (PF09733) In PDB | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | |
3 | D | Histone H3.1 | polymer | 11 | 1146.4 | 1 | UniProt (P68431) In PDB | Homo sapiens | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
4 | B | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
5 | B | N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide | non-polymer | 541.7 | 1 | Chemie (A97) | |||
6 | water | water | 18.0 | 636 | Chemie (HOH) |
Sequence modifications
A: 1 - 565 (UniProt: G0S8H7)
B: 191 - 2523 (UniProt: G0SDW4)
B: 2530 - 2691 (UniProt: G0RYC6)
PDB | External Database | Details |
---|---|---|
Met -39 | - | initiating methionine |
Ala -38 | - | expression tag |
Ser -37 | - | expression tag |
Ala -36 | - | expression tag |
Trp -35 | - | expression tag |
Ser -34 | - | expression tag |
His -33 | - | expression tag |
Pro -32 | - | expression tag |
Gln -31 | - | expression tag |
Phe -30 | - | expression tag |
Glu -29 | - | expression tag |
Lys -28 | - | expression tag |
Gly -27 | - | expression tag |
Gly -26 | - | expression tag |
Gly -25 | - | expression tag |
Ser -24 | - | expression tag |
Gly -23 | - | expression tag |
Gly -22 | - | expression tag |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Gly -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ala -16 | - | expression tag |
Trp -15 | - | expression tag |
Ser -14 | - | expression tag |
His -13 | - | expression tag |
Pro -12 | - | expression tag |
Gln -11 | - | expression tag |
Phe -10 | - | expression tag |
Glu -9 | - | expression tag |
Lys -8 | - | expression tag |
Leu -7 | - | expression tag |
Glu -6 | - | expression tag |
Val -5 | - | expression tag |
Leu -4 | - | expression tag |
Phe -3 | - | expression tag |
Gln -2 | - | expression tag |
Gly -1 | - | expression tag |
Pro 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 182 | - | expression tag |
Asn 183 | - | expression tag |
His 184 | - | expression tag |
His 185 | - | expression tag |
His 186 | - | expression tag |
His 187 | - | expression tag |
His 188 | - | expression tag |
His 189 | - | expression tag |
Ala 190 | - | expression tag |
Ile 302 | Pro 302 | engineered mutation |
Tyr 304 | Arg 304 | engineered mutation |
- | Glu 849 | deletion |
Lys 850 | Glu 850 | engineered mutation |
Tyr 851 | Asn 851 | engineered mutation |
Met 852 | Lys 852 | engineered mutation |
Cys 853 | Val 853 | engineered mutation |
Phe 855 | Tyr 855 | engineered mutation |
Leu 2524 | - | linker |
Val 2525 | - | linker |
Pro 2526 | - | linker |
Arg 2527 | - | linker |
Gly 2528 | - | linker |
Ser 2529 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 173969.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1065.0 | |
All* | Total formula weight | 175034.4 |