7W6A
Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex
Summary for 7W6A
Entry DOI | 10.2210/pdb7w6a/pdb |
Descriptor | Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... (6 entities in total) |
Functional Keywords | mll family methyltransferases, product specificity, f/y switch, protein binding |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 42616.70 |
Authors | |
Primary citation | Li, Y.,Zhao, L.,Zhang, Y.,Wu, P.,Xu, Y.,Mencius, J.,Zheng, Y.,Wang, X.,Xu, W.,Huang, N.,Ye, X.,Lei, M.,Shi, P.,Tian, C.,Peng, C.,Li, G.,Liu, Z.,Quan, S.,Chen, Y. Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82:3810-3825.e8, 2022 Cited by PubMed: 36108631DOI: 10.1016/j.molcel.2022.08.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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