PDB: 222624 件ウェブページステータス検索Chemie searchBIRD

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8TZM	Solution structure for a putative Type I site-specific deoxyribonuclease from Neisseria gonorrhoeae (NCCP11945). Seattle Structural Genomics Center for Infectious Disease target NegoA.19201.a 分子名称: Type I site-specific deoxyribonuclease 著者 Buchko, G.W, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2023-08-27 公開日 2023-10-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a putative Type I site-specific deoxyribonuclease from Neisseria gonorrhoeae (NCCP11945). To Be Published
8TZL	Cryo-EM structure of Vibrio cholerae FtsE/FtsX/EnvC complex, full-length 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... 著者 Hao, A, Lee, S.-Y. 登録日 2023-08-27 公開日 2023-12-20 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae. Structure, 32, 2024
8TZK	Cryo-EM structure of Vibrio cholerae FtsE/FtsX/EnvC complex, shortened 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... 著者 Hao, A, Lee, S.-Y. 登録日 2023-08-27 公開日 2023-12-20 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae. Structure, 32, 2024
8TZJ	Cryo-EM structure of Vibrio cholerae FtsE/FtsX complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... 著者 Hao, A, Lee, S.-Y. 登録日 2023-08-27 公開日 2023-12-20 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (3.51 Å) 主引用文献 Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae. Structure, 32, 2024
8TZH	Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant) 分子名称: (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, E11 DARPin, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A. 登録日 2023-08-26 公開日 2023-12-06 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
8TZG	Structure of C-terminal LRRK2 bound to MLi-2 (I2020T mutant) 分子名称: (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... 著者 Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A. 登録日 2023-08-26 公開日 2023-12-06 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
8TZF	Structure of full length LRRK2 bound to GZD-824 (I2020T mutant) 分子名称: 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... 著者 Villagran-Suarez, A, Sanz-Murillo, M, Alegrio-Louro, J, Leschziner, A. 登録日 2023-08-26 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
8TZE	Structure of C-terminal half of LRRK2 bound to GZD-824 分子名称: 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, Leucine-rich repeat serine/threonine-protein kinase 2 著者 Villagran-Suarez, A, Sanz-Murillo, M, Alegrio-Louro, J, Leschziner, A. 登録日 2023-08-26 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
8TZD	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-OFS conformation (3DVA analysis) 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZC	Structure of C-terminal LRRK2 bound to MLi-2 (G2019S mutant) 分子名称: (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, E11 DARPin, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Sanz-Murillo, M, Villagran-Suarez, A, Alegrio-Louro, J, Leschziner, A. 登録日 2023-08-26 公開日 2023-12-06 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
8TZB	Structure of the C-terminal half of LRRK2 bound to GZD-824 (I2020T mutant) 分子名称: 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, Leucine-rich repeat serine/threonine-protein kinase 2, designed ankyrin repeat proteins E11 著者 Villagran-Suarez, A, Sanz-Murillo, M, Alegrio-Louro, J, Leschziner, A. 登録日 2023-08-26 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
8TZA	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 2, INT2-INT1-INT1 conformation 分子名称: N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.43 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ9	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 2, INT2-INT2-INT2 conformation 分子名称: N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ8	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT3 conformation 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.19 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ7	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 1, INT1-INT1-INT1 conformation 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxy-5'-O-(2-methylpropanoyl)cytidine, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ6	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with PSI-6206 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2'-deoxy-2'-fluoro-2'-methyluridine, SODIUM ION, ... 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.69 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ5	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with N-hydroxycytidine 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, N-hydroxycytidine, SODIUM ION, ... 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ4	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, subset reconstruction 分子名称: (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ3	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, consensus reconstruction 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.31 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ2	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in MSP2N2 nanodiscs, apo state 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Sodium/nucleoside cotransporter 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ1	Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Ribavirin 分子名称: 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, ... 著者 Wright, N.J, Lee, S.-Y. 登録日 2023-08-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.54 Å) 主引用文献 Antiviral drug recognition and elevator-type transport motions of CNT3. Nat.Chem.Biol., 2024
8TZ0	Structure of a bacterial E1-E2-Ubl complex (form 1) 分子名称: E1(BilD), E2(BilB), Ubl(BilA), ... 著者 Ye, Q, Chambers, L.R, Corbett, K.D. 登録日 2023-08-26 公開日 2024-06-12 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 A eukaryotic-like ubiquitination system in bacterial antiviral defence Nature, 2024
8TYZ	Structure of a bacterial E1-E2-Ubl complex (form 2) 分子名称: E1(BilD), E2(BilB), Ubl(BilA), ... 著者 Ye, Q, Chambers, L.R, Corbett, K.D. 登録日 2023-08-26 公開日 2024-06-12 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 A eukaryotic-like ubiquitination system in bacterial antiviral defence Nature, 2024
8TYY	Structure of a bacterial Ubl-deubiquitinase complex (form 2) 分子名称: DUB(BilC) E33A Mutant, Ubl(BilA), ZINC ION 著者 Ye, Q, Gong, M, Corbett, K.D. 登録日 2023-08-26 公開日 2024-06-12 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 A eukaryotic-like ubiquitination system in bacterial antiviral defence Nature, 2024
8TYX	Structure of a bacterial Ubl-deubiquitinase complex (form 1) 分子名称: DUB(BilC) E33A Mutant, Ubl(BilA), ZINC ION 著者 Ye, Q, Gong, M, Corbett, K.D. 登録日 2023-08-26 公開日 2024-06-12 最終更新日 2024-07-17 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 A eukaryotic-like ubiquitination system in bacterial antiviral defence Nature, 2024

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