8TZB

Structure of the C-terminal half of LRRK2 bound to GZD-824 (I2020T mutant)

Summary for 8TZB

Entry DOI	10.2210/pdb8tzb/pdb
EMDB information	41753
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 2, designed ankyrin repeat proteins E11, 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide (3 entities in total)
Functional Keywords	kinase inhibitors, kinase, gtpases, protein binding
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	306762.25
Authors	Villagran-Suarez, A.,Sanz-Murillo, M.,Alegrio-Louro, J.,Leschziner, A. (deposition date: 2023-08-26, release date: 2023-12-06, Last modification date: 2023-12-27)
Primary citation	Sanz Murillo, M.,Villagran Suarez, A.,Dederer, V.,Chatterjee, D.,Alegrio Louro, J.,Knapp, S.,Mathea, S.,Leschziner, A.E. Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9:eadk6191-eadk6191, 2023 Cited by PubMed: 38039358 DOI: 10.1126/sciadv.adk6191 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation