8TZH

Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant)

Summary for 8TZH

• Entry DOI: 10.2210/pdb8tzh/pdb
• Related: 8TXZ 8TZC 8TZG
• EMDB information: 41759
• Descriptor: E11 DARPin, Leucine-rich repeat serine/threonine-protein kinase 2, (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, ... (4 entities in total)
• Functional Keywords: gtpase, kinase, inhibitors, protein binding
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 307052.35

Authors

Sanz-Murillo, M.,Villagran-Suarez, A.,Alegrio Louro, J.,Leschziner, A. (deposition date: 2023-08-26, release date: 2023-12-06, Last modification date: 2023-12-13)

• Primary citation: Sanz Murillo, M.,Villagran Suarez, A.,Dederer, V.,Chatterjee, D.,Alegrio Louro, J.,Knapp, S.,Mathea, S.,Leschziner, A.E.; Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.; Sci Adv, 9:eadk6191-eadk6191, 2023; PubMed: 38039358; DOI: 10.1126/sciadv.adk6191

Experimental method

ELECTRON MICROSCOPY (3.9 Å)