8TZH
Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | E11 DARPin | polymer | 182 | 19766.9 | 1 | synthetic construct | ||
| 2 | B (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286462.8 | 1 | UniProt (Q5S007) Pfam (PF23744) Pfam (PF23745) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 3 | C (A) | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine | non-polymer | 379.5 | 1 | Chemie (A1N) | |||
| 4 | D (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 306229.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.7 | |
| All* | Total formula weight | 307052.4 |
