8TZH
Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | E11 DARPin | polymer | 182 | 19766.9 | 1 | synthetic construct | ||
| 2 | B (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286462.8 | 1 | UniProt (Q5S007) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) | Homo sapiens (human) | Dardarin |
| 3 | C (A) | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine | non-polymer | 379.5 | 1 | Chemie (A1N) | |||
| 4 | D (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 306229.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.7 | |
| All* | Total formula weight | 307052.4 |
