8TZG

Structure of C-terminal LRRK2 bound to MLi-2 (I2020T mutant)

Summary for 8TZG

Entry DOI	10.2210/pdb8tzg/pdb
Related	8TXZ
EMDB information	41758
Descriptor	Leucine-rich repeat serine/threonine-protein kinase 2, (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	gtpase, kinase, inhibitors, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	136436.06
Authors	Sanz-Murillo, M.,Villagran-Suarez, A.,Alegrio Louro, J.,Leschziner, A. (deposition date: 2023-08-26, release date: 2023-12-06, Last modification date: 2023-12-13)
Primary citation	Sanz Murillo, M.,Villagran Suarez, A.,Dederer, V.,Chatterjee, D.,Alegrio Louro, J.,Knapp, S.,Mathea, S.,Leschziner, A.E. Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9:eadk6191-eadk6191, 2023 Cited by PubMed: 38039358 DOI: 10.1126/sciadv.adk6191 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.7 Å)

Structure validation