8TZG
Structure of C-terminal LRRK2 bound to MLi-2 (I2020T mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 1190 | 135589.1 | 1 | UniProt (Q5S007) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 2 | B (A) | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine | non-polymer | 379.5 | 1 | Chemie (A1N) | |||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1333 - 2522 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Thr 2020 | Ile 2020 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 135589.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 847.0 | |
| All* | Total formula weight | 136436.1 |
