8TZC

Structure of C-terminal LRRK2 bound to MLi-2 (G2019S mutant)

Summary for 8TZC

• Entry DOI: 10.2210/pdb8tzc/pdb
• Related: 8TXZ
• EMDB information: 41754
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, E11 DARPin, (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, ... (5 entities in total)
• Functional Keywords: gtpase, kinase, inhibitors, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 156794.37

Authors

Sanz-Murillo, M.,Villagran-Suarez, A.,Alegrio-Louro, J.,Leschziner, A. (deposition date: 2023-08-26, release date: 2023-12-06, Last modification date: 2023-12-13)

• Primary citation: Sanz Murillo, M.,Villagran Suarez, A.,Dederer, V.,Chatterjee, D.,Alegrio Louro, J.,Knapp, S.,Mathea, S.,Leschziner, A.E.; Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.; Sci Adv, 9:eadk6191-eadk6191, 2023; PubMed: 38039358; DOI: 10.1126/sciadv.adk6191

Experimental method

ELECTRON MICROSCOPY (2.7 Å)