8TZC
Structure of C-terminal LRRK2 bound to MLi-2 (G2019S mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 1195 | 136204.8 | 1 | UniProt (Q5S007) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | Dardarin |
| 2 | B (B) | E11 DARPin | polymer | 182 | 19766.9 | 1 | synthetic construct | ||
| 3 | C (A) | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine | non-polymer | 379.5 | 1 | Chemie (A1N) | |||
| 4 | D (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 5 | E (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1333 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Ser 2019 | Gly 2019 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 155971.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.7 | |
| All* | Total formula weight | 156794.4 |
