8TZF

Structure of full length LRRK2 bound to GZD-824 (I2020T mutant)

Summary for 8TZF

• Entry DOI: 10.2210/pdb8tzf/pdb
• EMDB information: 41757
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, designed ankyrin repeat proteins E11, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: kinase inhibitors, kinase, gtpases, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 307193.39

Authors

Villagran-Suarez, A.,Sanz-Murillo, M.,Alegrio-Louro, J.,Leschziner, A. (deposition date: 2023-08-26, release date: 2023-12-06, Last modification date: 2023-12-27)

• Primary citation: Sanz Murillo, M.,Villagran Suarez, A.,Dederer, V.,Chatterjee, D.,Alegrio Louro, J.,Knapp, S.,Mathea, S.,Leschziner, A.E.; Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.; Sci Adv, 9:eadk6191-eadk6191, 2023; PubMed: 38039358; DOI: 10.1126/sciadv.adk6191

Experimental method

ELECTRON MICROSCOPY (3.4 Å)