8TZF
Structure of full length LRRK2 bound to GZD-824 (I2020T mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286450.7 | 1 | UniProt (Q5S007) Pfam (PF23744) Pfam (PF23745) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF25497) Pfam (PF00069) Pfam (PF23748) | Homo sapiens (human) | |
| 2 | B (B) | designed ankyrin repeat proteins E11 | polymer | 182 | 19766.9 | 1 | synthetic construct | ||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | D (A) | 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | non-polymer | 532.6 | 1 | Chemie (T3X) |
Sequence modifications
A: 1 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Thr 2020 | Ile 2020 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 306217.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 975.8 | |
| All* | Total formula weight | 307193.4 |
