7OH0
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5EMN
| Crystal Structure of Human NADPH-Cytochrome P450 Reductase(A287P mutant) | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Xia, C, Marohnic, C, Panda, S, Masters, B.S, Kim, J.J.K. | 登録日 | 2015-11-06 | 公開日 | 2016-08-17 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. J.Biol.Chem., 291, 2016
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5VYG
| Crystal structure of hFA9 EGF repeat with O-glucose trisaccharide | 分子名称: | CALCIUM ION, Coagulation factor IX, alpha-D-xylopyranose-(1-3)-alpha-D-xylopyranose-(1-3)-beta-D-glucopyranose | 著者 | Yu, H.J, Li, H.L. | 登録日 | 2017-05-25 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking J. Biol. Chem., 292, 2017
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7PG5
| Crystal Structure of PI3Kalpha | 分子名称: | GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | 登録日 | 2021-08-13 | 公開日 | 2022-08-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.20029068 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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7PG6
| Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | 登録日 | 2021-08-13 | 公開日 | 2022-08-24 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.49943733 Å) | 主引用文献 | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618, 2023
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5KMZ
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7LQH
| Cryo-EM of KFE8 thinner nanotube (class 2, 2-sub-1) | 分子名称: | KFE8 peptide | 著者 | Wang, F, Gnewou, O.M, Egelman, E.H, Conticello, V.P. | 登録日 | 2021-02-13 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Deterministic chaos in the self-assembly of beta sheet nanotubes from an amphipathic oligopeptide. Matter, 4, 2021
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7LQI
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7LQG
| Cryo-EM of the KFE8 thinner nanotube (class 1, C2) | 分子名称: | KFE8 peptide | 著者 | Wang, F, Gnewou, O.M, Egelman, E.H, Conticello, V.P. | 登録日 | 2021-02-13 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Deterministic chaos in the self-assembly of beta sheet nanotubes from an amphipathic oligopeptide. Matter, 4, 2021
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7LQE
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6HIH
| Cytochrome c prime beta from Methylococcus capsulatus (Bath) | 分子名称: | Cytochrome c, GLYCEROL, HEME C, ... | 著者 | Adams, H, Chicano, T.M, Hough, M.A. | 登録日 | 2018-08-29 | 公開日 | 2019-03-20 | 最終更新日 | 2019-05-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | One fold, two functions: cytochrome P460 and cytochromec'-beta from the methanotrophMethylococcus capsulatus(Bath). Chem Sci, 10, 2019
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5FA6
| wild type human CYPOR | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Xia, C, Marohnic, C, Panda, S, Masters, B.S, Kim, J.J.K. | 登録日 | 2015-12-11 | 公開日 | 2016-08-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. J.Biol.Chem., 291, 2016
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7N63
| X-ray structure of HCAN_0200, an aminotransferase from Helicobacter canadensis in complex with its external aldimine | 分子名称: | (2R,3R,4S,5S,6R)-3,5-dihydroxy-4-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}-6-methyltetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Griffiths, W.A, Heisdorf, C.J, Thoden, J.B, Holden, H.M. | 登録日 | 2021-06-07 | 公開日 | 2021-06-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis. Protein Sci., 30, 2021
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5IWL
| CD47-diabody complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5F9 diabody, Leukocyte surface antigen CD47, ... | 著者 | Di, W, Jude, K.M, Garcia, K.C. | 登録日 | 2016-03-22 | 公開日 | 2016-06-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J.Clin.Invest., 126, 2016
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5W5K
| Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with KV70 | 分子名称: | 10-{[4-(hydroxycarbamoyl)phenyl]methyl}-5lambda~4~-pyrido[3,2-b][1,4]benzothiazin-10-ium, Histone deacetylase 6, POTASSIUM ION, ... | 著者 | Porter, N.J, Christianson, D.W. | 登録日 | 2017-06-15 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. J.Med.Chem., 62, 2019
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1G2W
| E177S MUTANT OF THE PYRIDOXAL-5'-PHOSPHATE ENZYME D-AMINO ACID AMINOTRANSFERASE | 分子名称: | ACETATE ION, D-ALANINE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | 著者 | Lepore, B.W, Ringe, D. | 登録日 | 2000-10-21 | 公開日 | 2000-11-15 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Studies on an Active Site Residue, E177, That Affects Binding of the Coenzyme in D-Amino Acid Transaminase, and Mechanistic Studies on a Suicide Substrate Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins, 10th Annual International Symposium on Vitamin B6, 2000
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2ABJ
| Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate. | 分子名称: | Branched-chain-amino-acid aminotransferase, cytosolic, N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE, ... | 著者 | Ohren, J.F, Moreland, D.W, Rubin, J.R, Hu, H.L, McConnell, P.C, Mistry, A, Mueller, W.T, Scholten, J.D, Hasemann, C.H. | 登録日 | 2005-07-15 | 公開日 | 2006-06-27 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg.Med.Chem.Lett., 16, 2006
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5WTX
| Structure of Nop9 | 分子名称: | Nucleolar protein 9 | 著者 | Ye, K, Wang, B. | 登録日 | 2016-12-15 | 公開日 | 2017-01-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.074 Å) | 主引用文献 | Nop9 binds the central pseudoknot region of 18S rRNA Nucleic Acids Res., 45, 2017
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5ZLP
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5ELV
| Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution | 分子名称: | 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, CHLORIDE ION, ... | 著者 | Krintel, C, Juknaite, L, Frydenvang, K, Kastrup, J.S. | 登録日 | 2015-11-05 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophys.J., 110, 2016
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8AYK
| Crystal structure of D-amino acid aminotrensferase from Aminobacterium colombiense complexed with D-glutamate | 分子名称: | (~{Z})-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]pent-2-enedioic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aminotransferase class IV | 著者 | Matyuta, I.O, Boyko, K.M, Nikolaeva, A.Y, Shilova, S.A, Rakitina, T.V, Minyaev, M.E, Popov, V.O, Bezsudnova, E.Y. | 登録日 | 2022-09-02 | 公開日 | 2022-11-16 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | To the Understanding of Catalysis by D-Amino Acid Transaminases: A Case Study of the Enzyme from Aminobacterium colombiense. Molecules, 28, 2023
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6DAM
| Crystal structure of lanthanide-dependent methanol dehydrogenase XoxF from Methylomicrobium buryatense 5G | 分子名称: | LANTHANUM (III) ION, Lanthanide-dependent methanol dehydrogenase XoxF, PYRROLOQUINOLINE QUINONE, ... | 著者 | Deng, Y, Ro, S.Y, Rosenzweig, A.C. | 登録日 | 2018-05-01 | 公開日 | 2018-09-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure and function of the lanthanide-dependent methanol dehydrogenase XoxF from the methanotroph Methylomicrobium buryatense 5GB1C. J. Biol. Inorg. Chem., 23, 2018
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6YP6
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5X2V
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5X2Y
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