5W5K

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with KV70

Summary for 5W5K

Entry DOI	10.2210/pdb5w5k/pdb
Descriptor	Histone deacetylase 6, ZINC ION, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	histone deacetylase, hydrolase, tubulin deacetylase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	3
Total formula weight	122338.51
Authors	Porter, N.J.,Christianson, D.W. (deposition date: 2017-06-15, release date: 2018-06-27, Last modification date: 2023-10-04)
Primary citation	Vogerl, K.,Ong, N.,Senger, J.,Herp, D.,Schmidtkunz, K.,Marek, M.,Muller, M.,Bartel, K.,Shaik, T.B.,Porter, N.J.,Robaa, D.,Christianson, D.W.,Romier, C.,Sippl, W.,Jung, M.,Bracher, F. Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors. J.Med.Chem., 62:1138-1166, 2019 Cited by PubMed: 30645113 DOI: 10.1021/acs.jmedchem.8b01090 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation