7PG5

Crystal Structure of PI3Kalpha

Summary for 7PG5

Entry DOI	10.2210/pdb7pg5/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	pi3k, pik3ca, pik3r1, p110, p85, compound, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	159095.86
Authors	Gong, G.,Pinotsis, N.,Williams, R.L.,Vanhaesebroeck, B. (deposition date: 2021-08-13, release date: 2022-08-24, Last modification date: 2024-02-07)
Primary citation	Gong, G.Q.,Bilanges, B.,Allsop, B.,Masson, G.R.,Roberton, V.,Askwith, T.,Oxenford, S.,Madsen, R.R.,Conduit, S.E.,Bellini, D.,Fitzek, M.,Collier, M.,Najam, O.,He, Z.,Wahab, B.,McLaughlin, S.H.,Chan, A.W.E.,Feierberg, I.,Madin, A.,Morelli, D.,Bhamra, A.,Vinciauskaite, V.,Anderson, K.E.,Surinova, S.,Pinotsis, N.,Lopez-Guadamillas, E.,Wilcox, M.,Hooper, A.,Patel, C.,Whitehead, M.A.,Bunney, T.D.,Stephens, L.R.,Hawkins, P.T.,Katan, M.,Yellon, D.M.,Davidson, S.M.,Smith, D.M.,Phillips, J.B.,Angell, R.,Williams, R.L.,Vanhaesebroeck, B. A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration. Nature, 618:159-168, 2023 Cited by PubMed: 37225977 DOI: 10.1038/s41586-023-05972-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.20029074868 Å)

Structure validation