5EMN

Crystal Structure of Human NADPH-Cytochrome P450 Reductase(A287P mutant)

Summary for 5EMN

Entry DOI	10.2210/pdb5emn/pdb
Related	3QE2
Descriptor	NADPH--cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	human cypor, abs-like phenotype, flavoprotein, cytochrome p450 reductase, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	144282.61
Authors	Xia, C.,Marohnic, C.,Panda, S.,Masters, B.S.,Kim, J.J.K. (deposition date: 2015-11-06, release date: 2016-08-17, Last modification date: 2023-09-27)
Primary citation	McCammon, K.M.,Panda, S.P.,Xia, C.,Kim, J.J.,Moutinho, D.,Kranendonk, M.,Auchus, R.J.,Lafer, E.M.,Ghosh, D.,Martasek, P.,Kar, R.,Masters, B.S.,Roman, L.J. Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. J.Biol.Chem., 291:20487-20502, 2016 Cited by PubMed: 27496950 DOI: 10.1074/jbc.M116.716019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation