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5EMN

Crystal Structure of Human NADPH-Cytochrome P450 Reductase(A287P mutant)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003958molecular_functionNADPH-hemoprotein reductase activity
A0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006805biological_processxenobiotic metabolic process
A0006809biological_processnitric oxide biosynthetic process
A0007584biological_processresponse to nutrient
A0008047molecular_functionenzyme activator activity
A0008941molecular_functionnitric oxide dioxygenase NAD(P)H activity
A0009055molecular_functionelectron transfer activity
A0009410biological_processresponse to xenobiotic stimulus
A0009437biological_processcarnitine metabolic process
A0009725biological_processresponse to hormone
A0009812biological_processflavonoid metabolic process
A0010181molecular_functionFMN binding
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016787molecular_functionhydrolase activity
A0019395biological_processfatty acid oxidation
A0019899molecular_functionenzyme binding
A0022900biological_processelectron transport chain
A0032332biological_processpositive regulation of chondrocyte differentiation
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0043602biological_processnitrate catabolic process
A0045880biological_processpositive regulation of smoothened signaling pathway
A0046210biological_processnitric oxide catabolic process
A0047726molecular_functioniron-cytochrome-c reductase activity
A0050660molecular_functionflavin adenine dinucleotide binding
A0050661molecular_functionNADP binding
A0061913biological_processpositive regulation of growth plate cartilage chondrocyte proliferation
A0070988biological_processdemethylation
A0071371biological_processcellular response to gonadotropin stimulus
A0071372biological_processcellular response to follicle-stimulating hormone stimulus
A0071375biological_processcellular response to peptide hormone stimulus
A0071548biological_processresponse to dexamethasone
A0090031biological_processpositive regulation of steroid hormone biosynthetic process
A0090346biological_processorganofluorine metabolic process
B0003958molecular_functionNADPH-hemoprotein reductase activity
B0004128molecular_functioncytochrome-b5 reductase activity, acting on NAD(P)H
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0006805biological_processxenobiotic metabolic process
B0006809biological_processnitric oxide biosynthetic process
B0007584biological_processresponse to nutrient
B0008047molecular_functionenzyme activator activity
B0008941molecular_functionnitric oxide dioxygenase NAD(P)H activity
B0009055molecular_functionelectron transfer activity
B0009410biological_processresponse to xenobiotic stimulus
B0009437biological_processcarnitine metabolic process
B0009725biological_processresponse to hormone
B0009812biological_processflavonoid metabolic process
B0010181molecular_functionFMN binding
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016787molecular_functionhydrolase activity
B0019395biological_processfatty acid oxidation
B0019899molecular_functionenzyme binding
B0022900biological_processelectron transport chain
B0032332biological_processpositive regulation of chondrocyte differentiation
B0043066biological_processnegative regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0043602biological_processnitrate catabolic process
B0045880biological_processpositive regulation of smoothened signaling pathway
B0046210biological_processnitric oxide catabolic process
B0047726molecular_functioniron-cytochrome-c reductase activity
B0050660molecular_functionflavin adenine dinucleotide binding
B0050661molecular_functionNADP binding
B0061913biological_processpositive regulation of growth plate cartilage chondrocyte proliferation
B0070988biological_processdemethylation
B0071371biological_processcellular response to gonadotropin stimulus
B0071372biological_processcellular response to follicle-stimulating hormone stimulus
B0071375biological_processcellular response to peptide hormone stimulus
B0071548biological_processresponse to dexamethasone
B0090031biological_processpositive regulation of steroid hormone biosynthetic process
B0090346biological_processorganofluorine metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue FMN A 701
ChainResidue
ASER89
AGLY146
ALEU176
AGLY177
AASN178
ATYR181
AHIS183
APHE184
AASN185
AASP211
ALEU215
AGLN90
AHOH855
AHOH871
ATHR91
AGLY92
ATHR93
AALA94
AALA141
ATHR142
ATYR143

site_idAC2
Number of Residues22
Detailsbinding site for residue FAD A 702
ChainResidue
AARG427
AARG457
ATYR458
ATYR459
ASER460
ACYS475
AALA476
AVAL477
AVAL479
ATYR481
AGLY491
AVAL492
AALA493
ATHR494
ATRP679
AHOH824
AHOH826
AHOH833
AHOH839
AHOH848
AHOH869
AHOH874

site_idAC3
Number of Residues14
Detailsbinding site for residue NAP A 703
ChainResidue
AARG301
AGLY537
ATHR538
ACYS569
ASER599
AARG600
ALYS605
ATYR607
AGLN609
AASN637
AMET638
AASP641
AHOH806
AHOH889

site_idAC4
Number of Residues21
Detailsbinding site for residue FMN B 701
ChainResidue
BSER89
BGLN90
BTHR91
BGLY92
BTHR93
BALA94
BALA141
BTHR142
BTYR143
BGLY144
BGLY146
BLEU176
BGLY177
BASN178
BTYR181
BHIS183
BPHE184
BASN185
BASP211
BLEU215
BFAD702

site_idAC5
Number of Residues26
Detailsbinding site for residue FAD B 702
ChainResidue
BHOH808
BHOH815
BHOH823
BHOH838
BHOH862
AASN506
AGLY507
AGLY508
BARG427
BARG457
BTYR458
BTYR459
BSER460
BCYS475
BALA476
BVAL477
BVAL479
BTYR481
BGLY491
BVAL492
BALA493
BTHR494
BTHR538
BTRP679
BFMN701
BHOH804

site_idAC6
Number of Residues11
Detailsbinding site for residue NAP B 703
ChainResidue
BARG301
BGLY537
BTHR538
BCYS569
BSER599
BARG600
BLYS605
BTYR607
BGLN609
BMET638
BASP641

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues288
DetailsDomain: {"description":"Flavodoxin-like","evidences":[{"source":"HAMAP-Rule","id":"MF_03212","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues242
DetailsDomain: {"description":"FAD-binding FR-type","evidences":[{"source":"HAMAP-Rule","id":"MF_03212","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03212","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10048323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21808038","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03212","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21808038","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues22
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03212","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19483672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21808038","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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