5EMN
Crystal Structure of Human NADPH-Cytochrome P450 Reductase(A287P mutant)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | NADPH--cytochrome P450 reductase | polymer | 618 | 70156.0 | 2 | UniProt (P16435) Pfam (PF00258) Pfam (PF00667) Pfam (PF00175) In PDB | Homo sapiens (Human) | P450R |
2 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
3 | A, B | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
4 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
5 | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A, B: 67 - 680 (UniProt: P16435)
PDB | External Database | Details |
---|---|---|
Gly 63 | - | expression tag |
Ser 64 | - | expression tag |
His 65 | - | expression tag |
Met 66 | - | expression tag |
Leu 228 | Pro 225 | engineered mutation |
Pro 287 | Ala 284 | engineered mutation |
Val 503 | Ala 500 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 140312.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 3970.6 | |
All* | Total formula weight | 144282.6 |